PI-103, Free Base

• Supplier: Biorbyt
• Catalog: orb153627
• Prices: $264.00, $323.00, $357.00, $553.00, $867.00, $1,267.00, $1,377.00
• Sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 250 mg
• Cas Number: [371935-74-9]
• Pubchem: 9884685
• Chemical Name: 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol
• Formula: C19H16N4O3
• Molecular Weight: 348.36 g/mol
• Purity: >99% pure
• Description: PI-103 is acts as a dual inhibitor of class IA phosphatidylinositide 3-kinase (PI3K) and mTOR. PIP3 activates Akt and mTOR, and plays important roles in cell growth and survival. PI-103 was mainly cytostatic for human leukemic cell lines and induced cell cycle arrest in the G1 phase. PI-103 inhibited endothelial cell proliferation and survival in vitro and tumor growth in vivo possibly by blocking activation of both PI3K and mTOR in vGPCR-expressing endothelial cells. PI-103 has been seen to have nominal effects inhibiting basal Na+ transport, but is very effective in abolishing insulin-induced Na+ absorption in the nephron.