A 943931 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4845
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1227675-50-4
• Chemical Name: 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine
• Formula: C17H21N5.2HCl
• Molecular Weight: 368.31
• Purity: >98 %
• Description: Potent and selective histamine H 4 receptor antagonist (pK i values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.

Product References

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class - Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class

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Molecular and biochemical pharmacology of the histamine H4 receptor. - Molecular and biochemical pharmacology of the histamine H4 receptor.

Leurs R, Chazot PL, Shenton FC, Lim HD, de Esch IJ. Br J Pharmacol. 2009 May;157(1):14-23.

Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion - Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion

Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R. J Pharmacol Exp Ther. 2014 Jun;349(3):508-17.