4-Acetyl-1,1-dimethylpiperazinium iodide

Name 4-Acetyl-1,1-dimethylpiperazinium iodide
Supplier Tocris Bioscience
Catalog 5619
Prices $125.00, $525.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 75667-84-4
Formula C8H17IN2O
Molecular Weight 284.14
Description Structural analog of acetylcholine that acts as a nicotinic agonist (K i = 29.9 nM at α 4 β 2). Upregulates the number of α 4 β 2 binding sites in M10 cells in vitro by 440%.
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Product References

Structural and electronic requirements for potent agonists at a nicotinic - Structural and electronic requirements for potent agonists at a nicotinic

Spivak CE, Gund TM, Liang RF, Waters JA. Eur J Pharmacol. 1986 Jan 14;120(1):127-31.

Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. - Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.

Spivak CE, Waters JA, Aronstam RS. Mol Pharmacol. 1989 Jul;36(1):177-84.

Regulation of nicotinic receptor subtypes following chronic nicotinic agonist - Regulation of nicotinic receptor subtypes following chronic nicotinic agonist

Warpman U, Friberg L, Gillespie A, Hellstrom-Lindahl E, Zhang X, Nordberg A. J Neurochem. 1998 May;70(5):2028-37.