| Name | (±)-AMG 487 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4330 |
| Prices | $235.00, $965.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Chemical Name | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide |
| Formula | C32H28F3N5O4 |
| Molecular Weight | 603.59 |
| Purity | >98 % |
| Description | Antagonist of CXCR3; inhibits binding of 125 I-IP-10 and 125 I-ITAC to CXCR3 (IC 50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC 50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. |
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