AMI-193

• Supplier: Tocris Bioscience
• Catalog: 5517
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 510-74-7
• Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
• Formula: C22H26FN3O2
• Molecular Weight: 383.46
• Purity: >99 %
• Description: Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Product References

Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a - Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a

Ismaiel AM, De Los Angeles J, Teitler M, Ingher S, Glennon RA. J Med Chem. 1993 Aug 20;36(17):2519-25.

Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, - Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist,

Czoty PW, Howell LL. Pharmacol Biochem Behav. 2000 Oct;67(2):257-64.