| Name | API-1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5736 |
| Prices | $299.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 36707-00-3 |
| Chemical Name | 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide |
| Formula | C13H15N5O6 |
| Molecular Weight | 337.29 |
| Purity | >96 % |
| Description | Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo . |
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