BL 1249

• Supplier: Tocris Bioscience
• Catalog: 5512
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 18200-13-0
• Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
• Formula: C17H17N5
• Molecular Weight: 291.35
• Purity: >99 %
• Description: Putative potassium channel activator; thought to act as a K 2P 2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC 50 values are 1.26 and 21.0 μ M for cultured bladder and aortic tissues respectively).

Product References

BL-1249 - BL-1249

Tertyshnikova S, Knox RJ, Plym MJ, Thalody G, Griffin C, Neelands T, Harden DG, Signor L, Weaver D, Myers RA, Lodge NJ. J Pharmacol Exp Ther. 2005 Apr;313(1):250-9. Epub 2004 Dec 17.

Investigation of the role of TASK-2 channels in rat pulmonary arteries; - Investigation of the role of TASK-2 channels in rat pulmonary arteries;

Gonczi M, Szentandrassy N, Johnson IT, Heagerty AM, Weston AH. Br J Pharmacol. 2006 Mar;147(5):496-505.