| Name | Centrinone |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5476 |
| Prices | $229.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1798871-30-3 |
| Chemical Name | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine |
| Formula | C26H25F2N7O6S2 |
| Molecular Weight | 633.65 |
| Purity | >98 % |
| Description | High affinity and selective PLK4 inhibitor (K i = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro . Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. |
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