CEP 1347

• Supplier: Tocris Bioscience
• Catalog: 5690
• Prices: $245.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 156177-65-0
• Chemical Name: (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacidmethylester
• Formula: C33H33N3O5S2
• Molecular Weight: 615.76
• Purity: >97 %
• Description: Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC 50 = 20 nM). Blocks A β -induced cortical neuron apoptosis (EC 50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective.

Product References

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the - Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the

Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E Jr, Murphy CA, Bartlett BA, Finn JP, Angeles T, Matsuda Y, Neff NT, Dionne CA. J Neurosci. 1998 Jan 1;18(1):104-11.

Preservation of cholinergic activity and prevention of neuron death by - Preservation of cholinergic activity and prevention of neuron death by

Saporito MS, Brown ER, Carswell S, DiCamillo AM, Miller MS, Murakata C, Neff NT, Vaught JL, Haun FA. Neuroscience. 1998 Sep;86(2):461-72.

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival - CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival

Bozyczko-Coyne D, O'Kane TM, Wu ZL, Dobrzanski P, Murthy S, Vaught JL, Scott RW. J Neurochem. 2001 May;77(3):849-63.