Clobenpropit dihydrobromide

• Supplier: Tocris Bioscience
• Catalog: 5582
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 145231-35-2
• Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothioureadihydrobromide
• Formula: C14H17ClN4S.2HBr
• Molecular Weight: 470.65
• Purity: >99 %
• Description: An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Product References

Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits - Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits

Yokoyama H, Onodera K, Maeyama K, Sakurai E, Iinuma K, Leurs R, Timmerman H, Watanabe T. Eur J Pharmacol. 1994 Jul 21;260(1):23-8.

Cloning and pharmacological characterization of a fourth histamine receptor - Cloning and pharmacological characterization of a fourth histamine receptor

Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW. Mol Pharmacol. 2001 Mar;59(3):420-6.

Histamine induces cytoskeletal changes in human eosinophils via the H(4) - Histamine induces cytoskeletal changes in human eosinophils via the H(4)

Buckland KF, Williams TJ, Conroy DM. Br J Pharmacol. 2003 Nov;140(6):1117-27. Epub 2003 Oct 6.