CX 546

• Supplier: Tocris Bioscience
• Catalog: 5495
• Prices: $129.00, $515.00
• Sizes: 10 mg, 50 mg
• Cas Number: 215923-54-9
• Chemical Name: (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
• Formula: C14H17NO3
• Molecular Weight: 247.29
• Purity: >99 %
• Description: AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. Neuroprotective in mice undergoing repeat ketamine anesthesia.

Product References

Mechanism and impact of allosteric AMPA receptor modulation by the ampakine - Mechanism and impact of allosteric AMPA receptor modulation by the ampakine

Nagarajan N, Quast C, Boxall AR, Shahid M, Rosenmund C. Neuropharmacology. 2001 Nov;41(6):650-63.

AMPA receptor potentiators for the treatment of CNS disorders. - AMPA receptor potentiators for the treatment of CNS disorders.

O'Neill MJ, Bleakman D, Zimmerman DM, Nisenbaum ES. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94.

Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via - Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via

Shimazaki T, Kaku A, Chaki S. Eur J Pharmacol. 2007 Dec 1;575(1-3):94-7. Epub 2007 Aug 14.