| Name | ( R )-DRF053 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5548 |
| Prices | $239.00, $985.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1241675-76-2 |
| Chemical Name | 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanoldihydrochloride |
| Formula | C23H27N7O.2HCl |
| Molecular Weight | 490.43 |
| Purity | >98 % |
| Description | Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC 50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC 50 = 4.1 μ M). Also shown to inhibit amyloid- β production in N2A-APP 695 cells. |
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