GR 127935 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5453
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 148642-42-6
• Chemical Name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamidehydrochloride
• Formula: C29H31N5O3.HCl
• Molecular Weight: 534.06
• Purity: >99 %
• Description: Potent and selective 5-HT 1B/1D receptor antagonist (pK i values are 8.5 for both guinea pig 5-HT 1D and rat 5-HT 1B receptors). Displays > 100-fold selectivity over 5HT 1A , 5-HT 2A , 5-HT 2C receptors and other receptor types. Centrally active following oral administration.

Product References

Evolution of a novel series of [(N,N-dimethylamino)propyl]- and - Evolution of a novel series of [(N,N-dimethylamino)propyl]- and

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Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a - Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a

De Vries P, Heiligers JP, Villalon CM, Saxena PR. Br J Pharmacol. 1996 May;118(1):85-92.

Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and - Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and

Knobelman DA, Hen R, Lucki I. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.