GS 39783

• Supplier: Tocris Bioscience
• Catalog: 5636
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 39069-52-8
• Chemical Name: N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• Formula: C15H23N5O2S
• Molecular Weight: 337.44
• Purity: >98 %
• Description: Positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

Product References

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and - N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K. J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. Epub 2003 Sep 3.

Behavioral characterization of the novel GABAB receptor-positive modulator - Behavioral characterization of the novel GABAB receptor-positive modulator

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. Epub 2004 Apr 27.

GABAB receptor-positive modulation-induced blockade of the rewarding properties - GABAB receptor-positive modulation-induced blockade of the rewarding properties

Mombereau C, Lhuillier L, Kaupmann K, Cryan JF. J Pharmacol Exp Ther. 2007 Apr;321(1):172-7. Epub 2007 Jan 10.