| Name | GSK 2830371 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5635 |
| Prices | $205.00, $845.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1404456-53-6 |
| Chemical Name | 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide |
| Formula | C23H29ClN4O2S |
| Molecular Weight | 461.02 |
| Purity | >98 % |
| Description | Potent and selective allosteric inhibitor of Wip1 phosphatase (IC 50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo . Orally bioavailable. |
| Supplier Page | Shop |