Ibudilast

Name Ibudilast
Supplier Tocris Bioscience
Catalog 5591
Prices $199.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 50847-11-5
Chemical Name 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Formula C14H18N2O
Molecular Weight 230.31
Purity >99 %
Description Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 μ M for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
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Product References

KC-404: a potential anti-allergic agent with antagonistic action against slow - KC-404: a potential anti-allergic agent with antagonistic action against slow

Nishino K, Ohkubo H, Ohashi M, Hara S, Kito J, Irikura T. Jpn J Pharmacol. 1983 Apr;33(2):267-78.

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on - Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on

Souness JE, Villamil ME, Scott LC, Tomkinson A, Giembycz MA, Raeburn D. Br J Pharmacol. 1994 Apr;111(4):1081-8.

Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and - Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and

Kishi Y, Ohta S, Kasuya N, Sakita S, Ashikaga T, Isobe M. Cardiovasc Drug Rev. 2001 Fall;19(3):215-25.