| Name | KH 7 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5260 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 330676-02-3 |
| Chemical Name | (±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide |
| Formula | C17H15BrN4O2S |
| Molecular Weight | 419.3 |
| Purity | >99 % |
| Description | Selective soluble adenylyl cyclase (sAC) inhibitor (IC 50 = 3 - 10 μ M in vivo ). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μ M. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μ M. |
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Stessin AM, Zippin JH, Kamenetsky M, Hess KC, Buck J, Levin LR. J Biol Chem. 2006 Jun 23;281(25):17253-8. Epub 2006 Apr 20.
Kumar S, Kostin S, Flacke JP, Reusch HP, Ladilov Y. J Biol Chem. 2009 May 29;284(22):14760-8.