Name | KRCA 0008 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 5475 |
Prices | $219.00, $905.00 |
Sizes | 10 mg, 50 mg |
Function Type | Inhibitor |
Cas Number | 1472795-20-2 |
Chemical Name | 1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone |
Formula | C30H37ClN8O4 |
Molecular Weight | 609.12 |
Purity | >99 % |
Description | Potent Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor (IC 50 values are 4 and 12 nM respectively). Inhibits lung cancer H3122 cell proliferation (IC 50 = 80 nM). Attenuates H3122 cell xenograft tumor growth in mice. Orally bioavailable. |
Supplier Page | Shop |
Park CH, Choe H, Jang IY, Kwon SY, Latif M, Lee HK, Lee HJ, Yang EH, Yun JI, Chae CH, Cho SY, Choi SU, Ha JD, Jung H, Kim HR, Kim P, Lee CO, Yun CS, Lee K. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.
Lee HJ, Latif M, Choe H, Ali I, Lee HK, Yang EH, Yun JI, Chae CH, Jung JK, Kim HR, Lee CO, Park CH, Lee K. Arch Pharm Res. 2014;37(9):1130-8.