| Name | LDN 193189 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5631 |
| Prices | $189.00, $795.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1435934-00-1 |
| Chemical Name | 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolinedihydrochloride |
| Formula | C25H22N6.2HCl |
| Molecular Weight | 479.4 |
| Purity | >98 % |
| Description | Potent and selective ALK2 and ALK3 inhibitor (IC 50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF- β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634). |
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