Mps1-IN-1 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5562
• Prices: $289.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Chemical Name: 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinoldihydrochloride
• Formula: C28H33N5O4S.2HCl
• Molecular Weight: 608.58
• Purity: >98 %
• Description: Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC 50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

Product References

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. - Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Nat Chem Biol. 2010 May;6(5):359-68.

A chemical tool box defines mitotic and interphase roles for Mps1 kinase. - A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

Lan W, Cleveland DW. J Cell Biol. 2010 Jul 12;190(1):21-4.

High-throughput kinase profiling: a more efficient approach toward the discovery - High-throughput kinase profiling: a more efficient approach toward the discovery

Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. Chem Biol. 2011 Jul 29;18(7):868-79.