MSG 606

• Supplier: Tocris Bioscience
• Catalog: 5641
• Prices: $245.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 1416983-77-1
• Formula: C62H82N20O13S
• Molecular Weight: 1347.51
• Description: Potent human MC 1 receptor antagonist (IC 50 = 17 nM). Also partial agonist at human MC 3 and MC 5 receptors (EC 50 values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro . Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γ MSH analog.

Product References

Autoradiographic discrimination of melanocortin receptors indicates that the MC3 - Autoradiographic discrimination of melanocortin receptors indicates that the MC3

Lindblom J, Schioth HB, Larsson A, Wikberg JE, Bergstrom L. Brain Res. 1998 Nov 9;810(1-2):161-71.

Melanocortins and cardiovascular regulation. - Melanocortins and cardiovascular regulation.

Versteeg DH, Van Bergen P, Adan RA, De Wildt DJ. Eur J Pharmacol. 1998 Oct 30;360(1):1-14.

Opposite effects of gamma(1)- and gamma(2)-melanocyte stimulating hormone on - Opposite effects of gamma(1)- and gamma(2)-melanocyte stimulating hormone on

Jansone B, Bergstrom L, Svirskis S, Lindblom J, Klusa V, Wikberg JE. Neurosci Lett. 2004 May 6;361(1-3):68-71.