Naloxone benzoylhydrazone

• Supplier: Tocris Bioscience
• Catalog: 5684
• Prices: $115.00, $485.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 119630-94-3
• Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]benzoicacidhydrazide
• Formula: C26H27N3O4
• Molecular Weight: 445.52
• Purity: >99 %
• Description: Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ , a partial agonist at μ and δ opioid receptors (pEC 50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [ 35 S]GTP γ S binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ -, μ - and δ -mediated analgesia and blocks NOP-induced supraspinal nociception.

Product References

Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone - Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone

Gistrak MA, Paul D, Hahn EF, Pasternak GW. J Pharmacol Exp Ther. 1989 Nov;251(2):469-76.

Has the sun set on kappa3-opioid receptors? - Has the sun set on kappa3-opioid receptors?

Connor M, Kitchen I. Br J Pharmacol. 2006 Feb;147(4):349-50.

Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid - Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid

Olianas MC, Concas D, Onali P. Br J Pharmacol. 2006 Feb;147(4):360-70.