1-Naphthyl PP1

Name 1-Naphthyl PP1
Supplier Tocris Bioscience
Catalog 5522
Prices $255.00, $1,045.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 221243-82-9
Chemical Name 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Formula C19H19N5
Molecular Weight 317.39
Purity >99 %
Description Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC 50 values are 1.0, 0.6, 0.6, 18 and 22 μ M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC 50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
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