NS 11021

Name NS 11021
Supplier Tocris Bioscience
Catalog 5398
Prices $185.00, $755.00
Sizes 10 mg, 50 mg
Function Type Activator
Cas Number 956014-19-0
Chemical Name N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Formula C16H9BrF6N6S
Molecular Weight 511.24
Purity >98 %
Description Activator of large-conductance Ca 2+ -activated potassium channels (BK Ca , K Ca 1.1). Exhibits no modulatory effect on a variety of K + (K V ), Na + and Ca 2+ currents at concentrations <10 μ M. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BK Ca in open and closed conformations; thought to bind the α subunit.
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