Name | NS 11021 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 5398 |
Prices | $185.00, $755.00 |
Sizes | 10 mg, 50 mg |
Function Type | Activator |
Cas Number | 956014-19-0 |
Chemical Name | N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea |
Formula | C16H9BrF6N6S |
Molecular Weight | 511.24 |
Purity | >98 % |
Description | Activator of large-conductance Ca 2+ -activated potassium channels (BK Ca , K Ca 1.1). Exhibits no modulatory effect on a variety of K + (K V ), Na + and Ca 2+ currents at concentrations <10 μ M. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BK Ca in open and closed conformations; thought to bind the α subunit. |
Supplier Page | Shop |
Bentzen BH, Nardi A, Calloe K, Madsen LS, Olesen SP, Grunnet M. Mol Pharmacol. 2007 Oct;72(4):1033-44. Epub 2007 Jul 16.
Kun A, Matchkov VV, Stankevicius E, Nardi A, Hughes AD, Kirkeby HJ, Demnitz J, Simonsen U. Br J Pharmacol. 2009 Nov;158(6):1465-76.
Layne JJ, Nausch B, Olesen SP, Nelson MT. Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R378-84. doi: