NSC 663284

• Supplier: Tocris Bioscience
• Catalog: 5287
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 383907-43-5
• Chemical Name: 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
• Formula: C15H16ClN3O3
• Molecular Weight: 321.76
• Purity: >99 %
• Description: Potent, selective inhibitor of Cdc25 dual specificity phosphatases (K i values are 29, 95 and 89 nM for human Cdc25A, Cdc25B 2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G 1 and G 2 /M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC 50 = 0.2 - 35 μ M).

Product References

Discovery and biological evaluation of a new family of potent inhibitors of the - Discovery and biological evaluation of a new family of potent inhibitors of the

Lazo JS, Aslan DC, Southwick EC, Cooley KA, Ducruet AP, Joo B, Vogt A, Wipf P. J Med Chem. 2001 Nov 22;44(24):4042-9.

Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor - Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor

Pu L, Amoscato AA, Bier ME, Lazo JS. J Biol Chem. 2002 Dec 6;277(49):46877-85. Epub 2002 Sep 27.

Redox regulation of Cdc25B by cell-active quinolinediones. - Redox regulation of Cdc25B by cell-active quinolinediones.

Brisson M, Nguyen T, Wipf P, Joo B, Day BW, Skoko JS, Schreiber EM, Foster C, Bansal P, Lazo JS. Mol Pharmacol. 2005 Dec;68(6):1810-20. Epub 2005 Sep 9.