| Name | PF 06463922 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5716 |
| Prices | $155.00, $645.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1454846-35-5 |
| Chemical Name | (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile |
| Formula | C21H19FN6O2 |
| Molecular Weight | 406.41 |
| Purity | >98 % |
| Description | High affinity and selective ALK and ROS1 inhibitor (K i values are <0.02, <0.07 and 0.7 nM for ROS1, wild-type ALK and ALK-L1196M, respectively). Exhibits >100-fold selectivity for ROS1 over a panel of 204 other kinases. Inhibits proliferation of BaF3 cells containing crizotinib -resistant ROS1 mutation in vitro . Inhibits tumor growth in relevant mouse models. Orally available and brain penetrant. |
| Supplier Page | Shop |