PNU 109291

• Supplier: Tocris Bioscience
• Catalog: 5697
• Prices: $239.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 187665-60-7
• Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide
• Formula: C24H31N3O3
• Molecular Weight: 409.52
• Purity: >98 %
• Description: Potent and selective 5-HT 1D receptor agonist that displays > 600-fold selectivity over 5-HT 1A and 5-HT 2A receptors and no activity at 5-HT 1B , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 6 and 5-HT 7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Product References

Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new - Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new

Ennis MD, Ghazal NB, Hoffman RL, Smith MW, Schlachter SK, Lawson CF, Im WB, Pregenzer JF, Svensson KA, Lewis RA, Hall ED, Sutter DM, Harris LT, McCall RB. J Med Chem. 1998 Jun 18;41(13):2180-3.

Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically - Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically

Cutrer FM, Yu XJ, Ayata G, Moskowitz MA, Waeber C. Neuropharmacology. 1999 Jul;38(7):1043-53.

5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and - 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and

Bhattacharya A, Schenck KW, Xu YC, Nisenbaum L, Galbreath E, Cohen ML. J Pharmacol Exp Ther. 2004 May;309(2):825-32. Epub 2004 Jan 14.