SR 140333

• Supplier: Tocris Bioscience
• Catalog: 5431
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 153050-21-6
• Chemical Name: 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octanechloride
• Formula: C37H45Cl3N2O2
• Molecular Weight: 656.12
• Purity: >97 %
• Description: Potent NK 1 receptor antagonist (K i = 0.74 nM. IC 50 = 1.6 nM). Inhibits substance P -invoked calcium mobilization and outward current (IC 50 = 1.3 nM); blocks NK 1 -mediated nitric oxide-dependent vasodilation in vivo .

Product References

In vitro and in vivo biological activities of SR140333, a novel potent - In vitro and in vivo biological activities of SR140333, a novel potent

Emonds-Alt X, Doutremepuich JD, Heaulme M, Neliat G, Santucci V, Steinberg R, Vilain P, Bichon D, Ducoux JP, Proietto V, et al.. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.

Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent - Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent

Hall JM, Brain SD. Br J Pharmacol. 1994 Oct;113(2):522-6.

SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 - SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1

Oury-Donat F, Lefevre IA, Thurneyssen O, Gauthier T, Bordey A, Feltz P, Emonds-Alt X, Le Fur G, Soubrie P. J Neurochem. 1994 Apr;62(4):1399-407.

Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase - Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase

Nieuwmeyer F, Ye J, Huizinga JD. J Pharmacol Exp Ther. 2006 Apr;317(1):439-45. Epub 2005 Dec 5.