| Name | SSR 69071 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5559 |
| Prices | $205.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 344930-95-6 |
| Chemical Name | 2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one |
| Formula | C27H32N4O7S |
| Molecular Weight | 556.63 |
| Purity | >98 % |
| Description | High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC 50 = 3.9 nM). Displays species-selectivity (K i values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID 50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active. |
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Bidouard JP, Duval N, Kapui Z, Herbert JM, O'Connor SE, Janiak P. Eur J Pharmacol. 2003 Feb 7;461(1):49-52.
Kapui Z, Varga M, Urban-Szabo K, Mikus E, Szabo T, Szeredi J, Batori S, Finance O, Aranyi P. J Pharmacol Exp Ther. 2003 May;305(2):451-9. Epub 2003 Feb 11.
Varga M, Kapui Z, Batori S, Nagy LT, Vasvari-Debreczy L, Mikus E, Urban-Szabo K, Aranyi P. Eur J Med Chem. 2003 Apr;38(4):421-5.