VDM 11

• Supplier: Tocris Bioscience
• Catalog: 5680
• Prices: $99.00, $419.00
• Sizes: 5 mg, 25 mg
• Function Type: Agonist
• Cas Number: 313998-81-1
• Chemical Name: (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
• Formula: C27H39NO2
• Molecular Weight: 409.61
• Purity: >98 %
• Description: A potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC 50 values of 4-11 μ M. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB 1 and CB 2 receptors. K i values are > 5-10 μ M at CB 1 and CB 2 . Active in vivo . Also available in water-soluble emulsion (Cat. No. 1686).

Product References

Overlap between the ligand recognition properties of the anandamide transporter - Overlap between the ligand recognition properties of the anandamide transporter

De Petrocellis L, Bisogno T, Davis JB, Pertwee RG, Di Marzo V. FEBS Lett. 2000 Oct 13;483(1):52-6.

The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of - The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of

Bisogno T, MacCarrone M, De Petrocellis L, Jarrahian A, Finazzi-Agro A, Hillard C, Di Marzo V. Eur J Biochem. 2001 Apr;268(7):1982-9.

The activity of anandamide at vanilloid VR1 receptors requires facilitated - The activity of anandamide at vanilloid VR1 receptors requires facilitated

De Petrocellis L, Bisogno T, Maccarrone M, Davis JB, Finazzi-Agro A, Di Marzo V. J Biol Chem. 2001 Apr 20;276(16):12856-63. Epub 2001 Jan 26.

Experimental parkinsonism alters endocannabinoid degradation: implications for - Experimental parkinsonism alters endocannabinoid degradation: implications for

Gubellini P, Picconi B, Bari M, Battista N, Calabresi P, Centonze D, Bernardi G, Finazzi-Agro A, Maccarrone M. J Neurosci. 2002 Aug 15;22(16):6900-7.