AZD 3988

• Supplier: Tocris Bioscience
• Catalog: 5615
• Prices: $309.00, $1,265.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 892489-52-0
• Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneaceticacid
• Formula: C23H22F2N4O4
• Molecular Weight: 456.44
• Purity: >98 %
• Description: Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC 50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, K v 11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

Product References

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 - Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1

McCoull W, Addie MS, Birch AM, Birtles S, Buckett LK, Butlin RJ, Bowker SS, Boyd S, Chapman S, Davies RD, Donald CS, Green CP, Jenner C, Kemmitt PD, Leach AG, Moody GC, Gutierrez PM, Newcombe NJ, Nowak T, Packer MJ, Plowright AT, Revill J, Schofield P, Sheldon C, Stokes S, Turnbull AV, Wang SJ, Whalley DP, Wood JM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8.