CITCO

• Supplier: Tocris Bioscience
• Catalog: 5763
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 338404-52-7
• Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
• Formula: C19H12Cl3N3OS
• Molecular Weight: 436.74
• Purity: >98 %
• Description: Constitutive androstane receptor (CAR) agonist (EC 50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ER α , ER β , PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro .

Product References

Identification of a novel human constitutive androstane receptor (CAR) agonist - Identification of a novel human constitutive androstane receptor (CAR) agonist

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. J Biol Chem. 2003 May 9;278(19):17277-83. Epub 2003 Feb 27.

A single amino acid controls the functional switch of human constitutive - A single amino acid controls the functional switch of human constitutive

Chen T, Tompkins LM, Li L, Li H, Kim G, Zheng Y, Wang H. J Pharmacol Exp Ther. 2010 Jan;332(1):106-15.