Deguelin

Name Deguelin
Supplier Tocris Bioscience
Catalog 5764
Prices $189.00
Sizes 10 mg
Cas Number 522-17-8
Chemical Name (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Formula C23H22O6
Molecular Weight 394.42
Purity >97 %
Description Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC 50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo .
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Product References

Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and - Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and

Takatsuki A, Nakatani N, Morimoto M, Tamura G, Matsui M, Arima K, Yamaguchi I, Misato T. Appl Microbiol. 1969 Oct;18(4):660-7.

Cancer chemopreventive activity mediated by deguelin, a naturally occurring - Cancer chemopreventive activity mediated by deguelin, a naturally occurring

Udeani GO, Gerhauser C, Thomas CF, Moon RC, Kosmeder JW, Kinghorn AD, Moriarty RM, Pezzuto JM. Cancer Res. 1997 Aug 15;57(16):3424-8.

Anticancer action of cube insecticide: correlation for rotenoid constituents - Anticancer action of cube insecticide: correlation for rotenoid constituents

Fang N, Casida JE. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4.

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and - Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and

Chun KH, Kosmeder JW 2nd, Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY. J Natl Cancer Inst. 2003 Feb 19;95(4):291-302.