DEL 22379

Name DEL 22379
Supplier Tocris Bioscience
Catalog 5734
Prices $185.00, $755.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 181223-80-3
Chemical Name N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Formula C26H28N4O3
Molecular Weight 444.53
Purity >98 %
Description ERK dimerization inhibitor (IC 50 ~ 0.5 μ M); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro . Induces apoptosis and prevents tumor progression in vivo .
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Product References

U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. - U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.

Dueweke TJ, Poppe SM, Romero DL, Swaney SM, So AG, Downey KM, Althaus IW, Reusser F, Busso M, Resnick L, et al.. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.

In vitro inhibition of human immunodeficiency virus type 1 by a combination of - In vitro inhibition of human immunodeficiency virus type 1 by a combination of

Pagano PJ, Chong KT. J Infect Dis. 1995 Jan;171(1):61-7.