| Name | GW 3965 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5673 |
| Prices | $115.00, $249.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Agonist |
| Cas Number | 405911-17-3 |
| Chemical Name | 3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneaceticacidhydrochloride |
| Formula | C33H31NO3ClF3.HCl |
| Molecular Weight | 618.51 |
| Purity | >98 % |
| Description | Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis. |
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Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. J Med Chem. 2002 May 9;45(10):1963-6.
Leik CE, Carson NL, Hennan JK, Basso MD, Liu QY, Crandall DL, Nambi P. Br J Pharmacol. 2007 Jun;151(4):450-6. Epub 2007 Apr 10.