Iressa

• Supplier: Tocris Bioscience
• Catalog: 5798
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 184475-35-2
• Chemical Name: N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
• Formula: C22H24ClFN4O3
• Molecular Weight: 446.9
• Purity: >98 %
• Description: Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23 - 79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts.

Product References

ZD1839 ('Iressa') as an anticancer agent. - ZD1839 ('Iressa') as an anticancer agent.

Baselga J, Averbuch SD. Drugs. 2000;60 Suppl 1:33-40; discussion 41-2.

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer - Antitumor effect and potentiation of cytotoxic drugs activity in human cancer

Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, Bianco AR, Tortora G. Clin Cancer Res. 2000 May;6(5):2053-63.

Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor - Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor

McKillop D, Partridge EA, Kemp JV, Spence MP, Kendrew J, Barnett S, Wood PG, Giles PB, Patterson AB, Bichat F, Guilbaud N, Stephens TC. Mol Cancer Ther. 2005 Apr;4(4):641-9.