NVP DPP 728 dihydrochloride

Name NVP DPP 728 dihydrochloride
Supplier Tocris Bioscience
Catalog 5660
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 207556-62-5
Chemical Name 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride
Formula C15H18N6O.2HCl
Molecular Weight 371.27
Purity >97 %
Description Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (K i = 11 nM, IC 50 = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo ; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.
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Product References

NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- - NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-

Hughes TE, Mone MD, Russell ME, Weldon SC, Villhauer EB. Biochemistry. 1999 Sep 7;38(36):11597-603.

Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response - Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response

Mitani H, Takimoto M, Kimura M. Jpn J Pharmacol. 2002 Apr;88(4):451-8.

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and - Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and

Reimer MK, Holst JJ, Ahren B. Eur J Endocrinol. 2002 May;146(5):717-27.