| Name | PF 06273340 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5752 |
| Prices | $169.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1402438-74-7 |
| Chemical Name | N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide |
| Formula | C23H22ClN7O3 |
| Molecular Weight | 479.93 |
| Purity | >98 % |
| Description | Potent and selective pan-Trk inhibitor (IC 50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable. |
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Daher JP, Abdelmotilib HA, Hu X, Volpicelli-Daley LA, Moehle MS, Fraser KB, Needle E, Chen Y, Steyn SJ, Galatsis P, Hirst WD, West AB. J Biol Chem. 2015 Aug 7;290(32):19433-44.
Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, Galatsis P. J Med Chem. 2015 Jan 8;58(1):419-32.