| Name | PF 3644022 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5751 |
| Prices | $265.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1276121-88-0 |
| Chemical Name | (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one |
| Formula | C21H18N4OS |
| Molecular Weight | 374.46 |
| Purity | >98 % |
| Description | Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC 50 = 5.2 nM; K i = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC 50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models. |
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