| Name | Proxyfan oxalate |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5792 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 177708-09-7 |
| Chemical Name | 4-[3-(Phenylmethoxy)propyl]-1H-imidazoleoxalate |
| Formula | C13H16N2O.C2H2O4 |
| Molecular Weight | 306.32 |
| Purity | >98 % |
| Description | High affinity histamine H 3 receptor ligand (pK i = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [ 3 H]-arachidonic acid release. |
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Baldi E, Bucherelli C, Schunack W, Cenni G, Blandina P, Passani MB. Neuropharmacology. 2005 Feb;48(2):246-51.
Krueger KM, Witte DG, Ireland-Denny L, Miller TR, Baranowski JL, Buckner S, Milicic I, Esbenshade TA, Hancock AA. J Pharmacol Exp Ther. 2005 Jul;314(1):271-81. Epub 2005 Apr 8.