SAG

• Supplier: Tocris Bioscience
• Catalog: 5772
• Prices: $155.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 912545-86-9
• Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
• Formula: C28H28ClN3OS
• Molecular Weight: 490.06
• Purity: >99 %
• Description: Potent Smoothened (Smo) receptor agonist (K d = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC 50 ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons.

Product References

Small molecule modulation of Smoothened activity. - Small molecule modulation of Smoothened activity.

Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. Epub 2002 Oct 21.

A small molecule that binds Hedgehog and blocks its signaling in human cells. - A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Nat Chem Biol. 2009 Mar;5(3):154-6.

Small molecules greatly improve conversion of human-induced pluripotent stem - Small molecules greatly improve conversion of human-induced pluripotent stem

Mak SK, Huang YA, Iranmanesh S, Vangipuram M, Sundararajan R, Nguyen L, Langston JW, Schule B. Stem Cells Int. 2012;2012:140427.