DL-TBOA

• Supplier: Tocris Bioscience
• Catalog: 2825
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 205309-81-5
• Chemical Name: DL-threo-β-Benzyloxyasparticacid
• Formula: C11H13NO5
• Molecular Weight: 239.23
• Purity: >98 %
• Description: A competitive, non-transportable blocker of excitatory amino acid transporters (IC 50 values are 70, 6, and 6 μ M for EAAT1, EAAT2 and EAAT3 respectively). Also inhibits EAAT4 and EAAT5 (K i values are 4.4 and 3.2 μ M respectively). Displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ .

Product References

DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid - DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid

Shimamoto K, Lebrun B, Yasuda-Kamatani Y, Sakaitani M, Shigeri Y, Yumoto N, Nakajima T. Mol Pharmacol. 1998 Feb;53(2):195-201.

Inhibition of uptake unmasks rapid extracellular turnover of glutamate of - Inhibition of uptake unmasks rapid extracellular turnover of glutamate of

Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gahwiler BH, Gerber U. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8733-8.

Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate - Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate

Shimamoto K, Shigeri Y, Yasuda-Kamatani Y, Lebrun B, Yumoto N, Nakajima T. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10.

Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid - Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid

Shigeri Y, Shimamoto K, Yasuda-Kamatani Y, Seal RP, Yumoto N, Nakajima T, Amara SG. J Neurochem. 2001 Oct;79(2):297-302.