A 987306

• Supplier: Tocris Bioscience
• Catalog: 5766
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1082954-71-9
• Chemical Name: (±)-(7aR*,11aR*)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine
• Formula: C18H25N5O
• Molecular Weight: 327.42
• Purity: >98 %
• Description: Potent histamine H 4 receptor antagonist (pK i values are 8.24 and 8.47 in human and rat H 4 receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H 3 , H 1 and H 2 receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED 50 = 42 μ mol/kg, ip).