| Name | PF 05105679 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5931 |
| Prices | $145.00 |
| Sizes | 10 mg |
| Function Type | Blocker |
| Cas Number | 1398583-31-7 |
| Chemical Name | 3-[[[(1R)-1-(4-Fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]benzoicacid |
| Formula | C26H21FN2O3 |
| Molecular Weight | 428.45 |
| Purity | >98 % |
| Description | Selective TRPM8 blocker (IC 50 = 103 nM). Exhibits >100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels. Reduces body temperature in rats and reverses cold-induced bladder capacity reduction in guinea pigs. Orally bioavailable. |
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