Dexamethasone
| Name | Dexamethasone |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 14776 |
| Prices | $49.00 |
| Sizes | 5 mg |
| Formula | C22H29FO5 |
| Molecular Weight | 392.5 g/mol |
| Purity | >98% |
| Description | Dexamethasone is a synthetic glucocorticoid that binds to the human glucocorticoid receptor (GR). Treatment of cells with dexamethasone leads to nuclear translocation and activation of GR. This elicits anti-inflammatory, cellular proliferation, and metabolic responses via GR-mediated transcriptional activation or repression of target genes (1-4). Research studies show that dexamethasone inhibits dendritic cell differentiation and maturation (5). The inhibition of nitric oxide synthase by dexamethasone has also been observed (6). |
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Product images
Western blot analysis of extracts from HeLa cells, serum-starved overnight and untreated (-) or treated with Dexamethasone (1 hr) at the indicated concentrations, using Phospho-Glucocorticoid Receptor (Ser211) Antibody #4161 (upper) and Glucocorticoid Receptor (D6H2L) XP ® Rabbit mAb #12041 (lower).
Western blot analysis of extracts from A549 cells, untreated (-) or treated with Dexamethasone (24 hr) at the indicated concentrations, using β-Arrestin 1 (D8O3J) Rabbit mAb #12697 (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Chemical structure of Dexamethasone.