Tyrphostin AG-490
| Name | Tyrphostin AG-490 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 14704 |
| Prices | $99.00 |
| Sizes | 10 mg |
| Formula | C17H14N2O3 |
| Molecular Weight | 294.30 g/mol |
| Purity | >99% |
| Description | Tyrphostin AG-490 is a membrane soluble protein tyrosine kinase inhibitor that primarily blocks Jak2 (IC 50 = 10 μM) and Jak3 (IC 50 = 20 μM) kinases (1,2). Research studies demonstrate that tyrphostin AG-490 inhibits proliferation and expansion of T cells (3). Unlike many other kinase inhibitors, tyrphostin AG-490 does not block a number of lymphocytic tyrosine kinases, such as Lck, Lyn, Btk, Syk, Jak1, Tyk2, or Src kinase (1,4). Additional studies indicate that tyrphostin AG-490 also selectively inhibits the EGFR (IC 50 = 2 μM) and ErbB2 (IC 50 = 13.5 μM) receptor tyrosine kinases (5). |
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Product images
Western blot analysis of extracts from NK-92 cells, serum-starved overnight and untreated (-) or treated with Human Interleukin-2 (hIL-2) #8907 (10 ng/ml, 15 min; +), either with or without Tyrphostin AG-490 pretreatment (1 hr) at the indicated concentrations, using Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb #5031, Jak3 (D1H3) Rabbit mAb #8827, Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb #9145, Stat3 (79D7) Rabbit mAb #4904, and β-Actin (D6A8) Rabbit mAb #8457.
Chemical structure of tyrphostin AG490