UNC1999
| Name | UNC1999 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 46080 |
| Prices | $49.00 |
| Sizes | 1 mg |
| Formula | C33H43N7O2 |
| Molecular Weight | 569.8 g/mol |
| Purity | >98% |
| Description | UNC1999 inhibits EZH2 and EZH1 histone-lysine N-methyltransferase activity through competitive inhibition of the cofactor S-Adenosyl-l-methionine (SAM). The UNC1999 inhibitor displays potent specificity relative to other histone methyltransferases. IC 50 values for EZH2 and EZH1 are 2 nM and 45 nM, respectively (1). Research studies demonstrate that UNC1999 effectively blocks histone H3 lysine 27 (H3K27) methylation. UNC1999 induces anti-proliferation, cell differentiation, and apoptosis, while exhibiting low cellular toxicity (1,2). |
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Product images
Western blot analysis of extracts from HeLa cells, untreated (-) or treated with UNC1999 (2 hr) at the indicated concentrations, using Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb #9733 (upper), Di-Methyl-Histone H3 (Lys27) (D18C8) XP ® Rabbit mAb #9728 (middle), and Histone H3 (D1H2) XP ® Rabbit mAb #4499 (lower).
Western blot analysis of extracts from HeLa cells, untreated (-) or treated with UNC1999 (5μM) at the indicated time points, using Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb #9733 (upper), Di-Methyl-Histone H3 (Lys27) (D18C8) XP ® Rabbit mAb #9728 (middle), and Histone H3 (D1H2) XP ® Rabbit mAb #4499 (lower).
Chemical structure of UNC1999