Tofacitinib

Name Tofacitinib
Supplier Cell Signaling Technology
Catalog 14703
Prices $99.00
Sizes 10 mg
Formula C16H20N6O
Molecular Weight 312.37 g/mol
Purity >99%
Description Tofacitinib is a cell permeable Janus kinase (JAK) inhibitor with demonstrated preference to inhibiting JAK1 and JAK3 (1). Tofacitinib inhibits JAK isoforms 1, 2, and 3 with IC 50 values of 6.1, 12, and 8.0 nM, respectively; the reported IC 50 value relative to Tyk2 is 176 nM (2). Research studies show that tofacitinib primarily blocks γ c cytokine receptors and inhibits cytokine production, which suggests that tofacitinib blocks cytokine action during both innate and adaptive responses (1,3). The overall effect of tofacitinib is to reduce inflammatory responses through selective inhibition of JAK family members (4).
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