Bafilomycin A1
| Name | Bafilomycin A1 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 54645 |
| Prices | $79.00 |
| Sizes | 100 µg |
| Formula | C35H58O9 |
| Molecular Weight | 622.83 g/mol |
| Purity | >98% |
| Description | Isolated from Streptomyces griseu s, bafilomycin A1 is a macrolide antibiotic that reversibly inhibits late phase autophagy (1,2). By inhibiting H + -ATPase, bafilomycin A1 prevents re-acidification of synaptic vesicles following exocytosis and thereby blocks fusion of autophagosomes and lysosomes (2-5). Research studies demonstrate that bafilomycin A1 can also inhibit cell proliferation (4). |
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Product images
Confocal immunofluorescent analysis of HeLa cells, untreated (left) or treated with Bafilomycin A1 (100 nM, 18 hr; right), using SQSTM1/p62 (D10E10) Rabbit mAb (IF Preferred) #7695 (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054. Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).
Confocal immunofluorescent analysis of HeLa cells, untreated (left) or treated with Bafilomycin A1 (200 nM, 18 hr; right), using NBR1 (D2E6) Rabbit mAb #9891 (green) and β-Actin (8H10D10) Mouse mAb #3700 (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).
Chemical structure of Bafilomycin A1.