GSK343
| Name | GSK343 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 66244 |
| Prices | $69.00 |
| Sizes | 1 mg |
| Formula | C31H39N7O2 |
| Molecular Weight | 541.7 g/mol |
| Purity | >98% |
| Description | GSK343 inhibits EZH2 and EZH1 histone-lysine N-methyltransferase activity through competitive inhibition of the cofactor S-Adenosyl-l-methionine (SAM). IC 50 values for EZH2 and EZH1 are 4 nM and 60 nM, respectively (1). Research studies show that GSK343 displays more than 1000-fold selectivity relative to other methyltransferases (1,2). These studies demonstrate that GSK343 induces cancer cell autophagy and enhances the anti-cancer effects of the multi-kinase inhibitor, sorafenib (3). |
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